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- Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after injury to totally different regions of the adult rat mind.
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As a control, a peptide of the same composition as the N-CAM decapeptide but of random sequence was infused on the contralateral facet of the brain. We consistently found that the population of dividing astrocytes was significantly smaller on the side during which N-CAM or one of many N-CAM-related molecules was infused than on the other facet. The inhibition was greatest in the cortical lesion websites (approximately 50%) and was much less pronounced in the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a considerably smaller population of dividing astrocytes than the websites on the other aspect. When N-CAM and basic fibroblast growth issue, which is understood to stimulate astrocyte division in vitro, were coinfused into cortical lesion sites, astrocyte proliferation was nonetheless inhibited. These outcomes recommend the speculation that, by decreasing glial proliferation, N-CAM or its peptides may help create an surroundings that is more appropriate for neuronal regeneration.
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Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin fundamental protein in growing sciatic nerve. Janeczko K. The proliferative response of S-100 protein-positive glial cells to harm in the neonatal rat mind. Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after injury to completely different regions of the adult rat brain. What used to take a Tricaster/Video Toaster setup can now be done in software using a regular PC. I can switch forwards and backwards between teacher view, demonstration camera, audience view, presentation slide deck or video, etc… and it’s seamless.
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Immunohistological Localization Of The Adhesion Molecules L1, N-cam, And Mag In The Growing And Adult Optic Nerve Of Mice
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